Glucose levels in mothers during pregnancy have important implications for the offspring, as exposure of the developing fetus to high glucose levels is associated with adverse outcomes at birth as well as obesity and abnormal glucose metabolism later in childhood and adulthood. Factors regulating glucose levels during pregnancy are not well understood. The goal of this five-year project is to define genetic factors that impact glucose levels and metabolism in mothers during pregnancy.http://upload.wikimedia.org/wikipedia/commons/4/43/NIH_logo.svg