A new Nature article, Epigenetics: The genome unwrapped, focuses on the work of the Roadmap Epigenomics Project, a collaboration of more than 90 laboratories, including the Reddy, Gersbach, and Crawford labs. The project investigates what the article calls "one of the central mysteries of biology: how do cells with the same genetic instructions take on wildly different identities?" The article also discusses a recent publication, co-authored by our lab and the Gersbach lab, Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.