The Reddy Lab is focused on understanding how genetic variation that alters gene regulation contributes to human traits including risk for common diseases such as diabetes. Several large association studies have revealed genetic variants that influence human traits.  What is not known is the mechanisms involves. Because most of these trait-associated variants are found far away from genes, we hypothesize that they act by altering the regulation of nearby genes. To test this hypothesis, we use an interdisciplinary combination of high-throughput genomics, computational biology, and traditional molecular biology and genetics experiments. We hope that, through our research, we can better understand the gene-regulatory bases for human evolution and human disease. Those findings will likely reveal new pathways of disease that can ultimately be targeted for novel diagnostics and treatment.



Center for Genomic and Computational Biology
Duke University
2347 CIEMAS Building
101 Science Drive
Durham, NC 27705